OvaScience, Inc.

9 Fourth Avenue

Waltham, Massachusetts 02451


December 3, 2018




United States Securities and Exchange Commission

Division of Corporation Finance

100 F Street, N.E.

Washington, D.C. 20549

Attention: Jeffrey Gabor


RE:                                                                          OvaScience, Inc.

Registration Statement on Form S-3 File No. 333-228209

Request for Acceleration of Effectiveness


Ladies and Gentlemen:


In accordance with Rule 461 promulgated under the Securities Act of 1933, as amended, OvaScience, Inc. (the “Company”) hereby requests acceleration of the effective date of the Registration Statement on Form S-3 (File No. 333-228209), as amended (the “Registration Statement”), so that it may become effective at 9:00 a.m., Washington, D.C. time on December 6, 2018, or as soon as possible thereafter.


The Company hereby authorizes Megan N. Gates, Esq. of Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C. to orally modify or withdraw this request for acceleration.


The Company respectfully requests that it be notified of such effectiveness by a telephone call to Ms. Gates at (617) 348-4443 and that such effectiveness also be confirmed in writing. Any questions regarding this request may be addressed to Ms. Gates.



Very truly yours,








/s/ Jonathan Gillis


Jonathan Gillis


Senior Vice President, Finance



OvaScience, Inc.


Christopher A. Kroeger., M.D., M.B.A., President and Chief Executive Officer




Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.


William C. Hicks, Esq.


Megan N. Gates, Esq.


Daniel A. Bagliebter, Esq.




Cooley, LLP


Miguel J. Vega, Esq.


Nicole Brookshire, Esq.