Washington, D.C. 20549


Filed pursuant to Section 16(a) of the Securities Exchange Act of 1934
or Section 30(h) of the Investment Company Act of 1940
OMB Number: 3235-0104
Estimated average burden
hours per response: 0.5
1. Name and Address of Reporting Person*
Simantov Ronit

(Last) (First) (Middle)


(City) (State) (Zip)
2. Date of Event Requiring Statement (Month/Day/Year)
3. Issuer Name and Ticker or Trading Symbol
Tempest Therapeutics, Inc. [ TPST ]
4. Relationship of Reporting Person(s) to Issuer
(Check all applicable)
X Director 10% Owner
Officer (give title below) Other (specify below)
5. If Amendment, Date of Original Filed (Month/Day/Year)
6. Individual or Joint/Group Filing (Check Applicable Line)
X Form filed by One Reporting Person
Form filed by More than One Reporting Person
Table I - Non-Derivative Securities Beneficially Owned
1. Title of Security (Instr. 4) 2. Amount of Securities Beneficially Owned (Instr. 4) 3. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 4. Nature of Indirect Beneficial Ownership (Instr. 5)
Table II - Derivative Securities Beneficially Owned
(e.g., puts, calls, warrants, options, convertible securities)
1. Title of Derivative Security (Instr. 4) 2. Date Exercisable and Expiration Date (Month/Day/Year) 3. Title and Amount of Securities Underlying Derivative Security (Instr. 4) 4. Conversion or Exercise Price of Derivative Security 5. Ownership Form: Direct (D) or Indirect (I) (Instr. 5) 6. Nature of Indirect Beneficial Ownership (Instr. 5)
Date Exercisable Expiration Date Title Amount or Number of Shares
Explanation of Responses:
No securities are beneficially owned.
/s/ Pierre Lorenzo (Attorney-in-Fact) 08/10/2021
** Signature of Reporting Person Date
Reminder: Report on a separate line for each class of securities beneficially owned directly or indirectly.
* If the form is filed by more than one reporting person, see Instruction 5 (b)(v).
** Intentional misstatements or omissions of facts constitute Federal Criminal Violations See 18 U.S.C. 1001 and 15 U.S.C. 78ff(a).
Note: File three copies of this Form, one of which must be manually signed. If space is insufficient, see Instruction 6 for procedure.
Persons who respond to the collection of information contained in this form are not required to respond unless the form displays a currently valid OMB Number.
                               POWER OF ATTORNEY

      Know all by these presents, that the undersigned hereby constitutes and
appoints Stephen Brady, Nicholas Maestas and Pierre Lorenzo of Tempest
Therapeutics, Inc. and Laura Berezin,Sepideh Mousakhani, Noel Ripberger-Scheick
and Nguyen X. Nguyen of Cooley LLP, or any of them signing singly, with full
power of substitution, the undersigned's true and lawful attorney in fact to:

      (1)  execute for and on behalf of the undersigned, in the undersigned's
capacity as an officer, director or beneficial owner of more than 10%  of a
registered  class  of  securities of Tempest Therapeutics, Inc. (the "Company"),
Forms  3, 4, and 5 (including any amedments thereto) in accordance with
Section  16(a) of the Securities Exchange Act of 1934, as amended (the "Exchange
Act") and the rules thereunder and a Form ID, Uniform Application for Access
Codes to File on EDGAR.

      (2)  do  and  perform any and all acts for an on behalf of the undersigned
that  may  be necessary or desirable to execute such Form 3,4 or 5, or Form ID
(including any amendments thereto) and timely file such forms with the United
States Securities and Exchange Commission and any stock exchange or similar
authority; and

      (3)  take any other action of any nature whatsoever in connection with the
foregoing  which, in the opinion of such attorney-in-fact, may be of benefit, in
the  best  interest  of,  or  legally  required  by,  the  undersigned, it being
understood that the documents executed by such attorney-in-fact on behalf of the
undersigned  pursuant  to this Power of Attorney shall be in such form and shall
contain  such  terms and conditions as such attorney-in-fact may approve in such
attorney-in-fact's discretion.

      The undersigned hereby grants to each such attorney-in-fact full power and
authority  to  do  and perform any and every act and thing whatsoever requisite,
necessary,  or proper to be done in the exercise of any of the rights and powers
herein granted, as fully to all intents and purposes as the undersigned might or
could  do  if personally present, with full power of substitution or revocation,
hereby  ratifying  and  confirming  all  that  such  attorney-in-fact,  or  such
attorney-in-fact's  substitute  or substitutes, shall lawfully do or cause to be
done  by  virtue  of  this  power  of  attorney and the rights and powers herein
granted.  The  undersigned acknowledges that the foregoing attorneys-in-fact, in
serving  in  such  capacity at the request of the undersigned, are not assuming,
nor is the Company assuming, any of the undersigned's responsibilities to comply
with Section 16 of the Exchange Act.

      This  Power  of  Attorney  shall remain in full force and effect until the
earliest  to occur of (a) the undersigned is no longer required to file Forms 3,
4  and  5  with  respect  to  the  undersigned's holdings of and transactions in
securities  issued by the Company, (b) revocation by the undersigned in a signed
writing  delivered  to  the  foregoing  attorneys-in-fact,  or  (c)  as  to  any
attorney-in-fact  individually,  until  such attorney-in-fact shall no longer be
employed by the Company or Cooley LLP.

      IN  WITNESS  WHEREOF, the undersigned has caused this Power of Attorney to
be executed as of this date:  8/7/2021.

                                                      /s/ Ronit Simantov
                                                     Ronit Simantov